Related Experiment Video
Updated: Apr 6, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges
Yaxing Zhang1,2, Xiao-Jing Zhang1,2, Hongliang Li1,2
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Background:
The pathological activation of innate immune system may contribute to the development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members, which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic diseases.
Objective:
The aim of this review is to summary the current knowledge of the biological functions of IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular remodeling, and stroke.
Results:
IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and - independent manners.
Conclusion:
IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic disorders.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy IV: Restrictive Cardiomyopathy
