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Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms

Seul Bee Lee1, Han Seul Choi1, Sejung Son1

  • 1Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.

Korean Circulation Journal
|August 5, 2015
PubMed

Insights

Respiratory symptoms in Kawasaki disease (KD) patients were linked to specific viruses and cardiac changes. N-terminal pro-brain natriuretic peptide (NT-proBNP) aids in differentiating KD from other febrile illnesses.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Cardiology

Background:

  • Respiratory symptoms are common in children with acute Kawasaki disease (KD).
  • The role of respiratory viruses in KD pathogenesis requires further investigation.
  • Tissue Doppler echocardiography and specific biomarkers are used to assess cardiac involvement.

Purpose of the Study:

  • To investigate the association between respiratory viruses and Kawasaki disease (KD).
  • To compare cardiac function and inflammatory markers in KD patients with and without respiratory symptoms.
  • To evaluate the diagnostic utility of NT-proBNP in differentiating KD from other febrile respiratory infections.

Main Methods:

  • 138 KD patients were divided into groups based on respiratory symptoms.
  • Multiplex RT-PCR was used to detect 14 respiratory viruses in nasopharyngeal secretions.
  • Echocardiography, including Tei index, and laboratory markers like NT-proBNP were analyzed.

Main Results:

  • 31.8% of KD patients presented with respiratory symptoms.
  • KD patients with respiratory symptoms showed longer fever duration and larger coronary artery diameters.
  • Elevated NT-proBNP, C-reactive protein, and Tei index were observed in KD patients with respiratory symptoms.

Conclusions:

  • NT-proBNP is a valuable biomarker for distinguishing KD from febrile viral respiratory infections.
  • Certain respiratory viruses may be more prevalent in KD patients.
  • Increased Tei index indicates cardiac involvement in KD patients with respiratory symptoms.
Abstract

Keywords:
Echocardiography, DopplerMucocutaneous lymph node syndromeNatriuretic peptide, brainRespiratory virusReverse transcriptase polymerase chain reaction

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