Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.2K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.2K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.7K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.7K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

2.8K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.8K
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

2.3K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
2.3K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.5K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

546
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
546

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spherical adsorptive carbon use and risks of dialysis initiation and mortality in advanced chronic kidney disease: a real-world cohort study.

Kidney research and clinical practice·2026
Same author

Higher cardiovascular risk observed with beta-blockers in CKD patients without prior cardiovascular disease.

Clinical kidney journal·2026
Same author

Perivascular space volume measurement at the inferior basal ganglia on cranial ultrasound in neonates: associations with germinal matrix hemorrhage and brain maturation.

Ultrasonography (Seoul, Korea)·2026
Same author

VSIG4 Expression During Renal Aging Is Accelerated by Type 2 Diabetes in Mice.

Life (Basel, Switzerland)·2026
Same author

Prevalence of polypharmacy and its association with clinical outcomes in kidney transplant recipients : results from the KNOW-KT study.

Kidney research and clinical practice·2026
Same author

Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study.

Communications medicine·2026

Related Experiment Video

Updated: Apr 6, 2026

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
07:59

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

11.9K

Loop Diuretics in Clinical Practice.

Se Won Oh1, Sang Youb Han1

  • 1Department of Internal Medicine, Inje University College of Medicine, Goyang, Korea.

Electrolyte & Blood Pressure : E & BP
|August 5, 2015
PubMed
Summary

Loop diuretics, like furosemide, effectively manage edema by increasing sodium and water excretion. Optimizing their use requires careful consideration of administration route, dosage, and patient-specific factors, especially in chronic kidney disease.

Keywords:
Chronic kidney diseaseFurosemideLoop diuretics

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.7K

Related Experiment Videos

Last Updated: Apr 6, 2026

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
07:59

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

11.9K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.7K

Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Diuretics are essential for managing edema in diverse clinical settings.
  • Loop diuretics are potent agents that inhibit renal sodium reabsorption, increasing urine output.

Purpose of the Study:

  • To review critical aspects of prescribing loop diuretics, focusing on furosemide.
  • To highlight considerations for optimizing furosemide efficacy, including administration and dosage.

Main Methods:

  • Review of five key prescribing aspects of furosemide.
  • Analysis of oral versus intravenous administration and continuous versus bolus infusion.
  • Examination of furosemide use in chronic kidney disease and associated side effects.

Main Results:

  • Furosemide bioavailability varies significantly between oral and intravenous routes.
  • Optimal furosemide dosage thresholds and ceiling doses are condition-dependent, particularly in severe edema or CKD.
  • Understanding delivery impact on bioavailability and dosage is crucial for maximizing therapeutic efficiency.

Conclusions:

  • Effective loop diuretic therapy, particularly with furosemide, necessitates a nuanced approach.
  • Prescribers must tailor administration route, dosage, and infusion method to individual patient needs and conditions like CKD.
  • Careful management of furosemide is vital for controlling edema and minimizing adverse effects.