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Prospects for future topical glucocorticoid development
1Research and Development Department, AB Draco, Lund, Sweden.
Acta Dermato-Venereologica. Supplementum
|January 1, 1989
Summary
Developing topical glucocorticoids with rapid local inactivation could reduce side effects. This approach may offer better control over steroid absorption and activity in the skin, potentially improving safety profiles.
Area of Science:
- Dermatology
- Pharmacology
- Biochemistry
Background:
- Current topical glucocorticoids are primarily metabolized in the liver.
- Systemic and local adverse reactions are significant concerns with existing glucocorticoids.
- Enhanced local inactivation could mitigate these adverse effects.
Purpose of the Study:
- To explore the potential of rapid extrahepatic biotransformation for improving topical glucocorticoid safety.
- To investigate glucocorticoids with local metabolic pathways for better absorption control.
- To identify characteristics of an ideal glucocorticoid for topical application.
Main Methods:
- Review of existing studies on glucocorticoid catabolism and concentration gradients in skin.
- Analysis of data on glucocorticoids with partial extrahepatic metabolism.
- Assessment of fibroblast inhibition by glucocorticoids.
Main Results:
- Glucocorticoids with rapid extrahepatic metabolism may offer autoregulating absorption.
- This autoregulation could lead to reduced systemic and local adverse reactions.
- Current locally metabolized glucocorticoids show moderate topical activity, with no confirmed reduced catabolic effects.
Conclusions:
- Designing glucocorticoids with high intrinsic activity and rapid skin metabolism is recommended.
- Further research is needed to develop novel topical glucocorticoids with improved safety and efficacy.
- Local inactivation during or immediately after absorption is a desirable characteristic.