Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

6.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.6K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.4K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
Stem Cell Culture01:17

Stem Cell Culture

6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tracking Cation Exchange in Individual Nanowires <i>via</i> Transistor Characterization.

ACS nano·2024
Same author

Superionic phase transition in individual silver selenide nanowires.

Nanoscale·2021
Same author

CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity.

Cancer research·2015
Same author

The influence of a Te-depleted surface on the thermoelectric transport properties of Bi₂Te₃ nanowires.

Nanotechnology·2014
Same author

Thermoelectric characterization of bismuth telluride nanowires, synthesized via catalytic growth and post-annealing.

Advanced materials (Deerfield Beach, Fla.)·2012
Same author

Imaging Schottky barriers and ohmic contacts in PbS quantum dot devices.

Nano letters·2012

Related Experiment Video

Updated: Apr 6, 2026

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.4K

Stem cell autotomy and niche interaction in different systems.

David C Dorn1, August Dorn1

  • 1David C Dorn, Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany.

World Journal of Stem Cells
|August 5, 2015
PubMed
Summary
This summary is machine-generated.

Male germline stem cells (GSCs) in insects exhibit autotomy, a process where projections fragment and interact with niche cells. This programmed cell death offers new insights into stem cell-niche communication and conserved autodestruction pathways.

Keywords:
ErythropoiesisMale germline stem cellsSpermatogenesisStem cell autotomyStem cell-niche interactionThrombopoiesis

More Related Videos

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.7K
Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

22.4K

Related Experiment Videos

Last Updated: Apr 6, 2026

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.4K
Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.7K
Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
09:17

Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

Published on: February 26, 2015

22.4K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Stem Cell Biology

Background:

  • Cell autotomy, exemplified by erythrocyte and platelet formation, is a known biological process.
  • Male germline stem cells (GSCs) in insects display autotomy, involving projections interacting with niche cells.
  • This phenomenon has been observed in various insect species, including moths and milkweed bugs.

Purpose of the Study:

  • To investigate the enigmatic interaction between GSCs and their niche, particularly focusing on GSC autotomy.
  • To explore potential conserved signaling pathways underlying GSC autotomy and compare them with known mechanisms in other systems.
  • To understand how GSC autotomy contributes to stem cell-niche communication.

Main Methods:

  • Comparative analysis of GSC-niche interactions across different insect species (moths, milkweed bugs, Drosophila).
  • Observation of GSC projection formation, fragmentation, and interaction with apical/hub cells.
  • Examination of autophagocytosis and disintegration of autotomized vesicles by niche cells.

Main Results:

  • GSCs form finger-like projections that undergo retrograde fragmentation with signs of autophagy.
  • Autotomized vesicles are either phagocytized by niche cells (gipsy moth) or accumulate and disintegrate (milkweed bug).
  • GSC autotomy shows similarities to axonal destruction processes, suggesting a conserved autodestruction program.

Conclusions:

  • GSC autotomy represents an alternative mode of stem cell-niche communication distinct from Drosophila models.
  • The process shares similarities with neuronal autodestruction, hinting at evolutionarily conserved pathways.
  • Further research into signaling pathways is crucial for understanding GSC autotomy and stem cell-niche interdependence.