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Updated: Apr 6, 2026
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A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
Published on: November 29, 2018
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Right ventricle failure associated wıth trastuzumab
Nermin Bayar1, Selçuk Küçükseymen2, Sevil Göktaş3
1Cardiology Department, Antalya Education and Research Hospital, Varlık mahallesi, Kazım Karabekir caddesi, Soğuksu-Antalya, Turkey.
Therapeutic Advances in Drug Safety
|August 5, 2015
Summary
Trastuzumab (TZ), a HER2-targeted therapy, can cause cardiotoxicity. This case report details a patient with breast cancer who experienced right ventricular dysfunction and heart failure, which resolved after discontinuing TZ.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Trastuzumab (TZ) is a monoclonal antibody targeting HER2, crucial for treating HER2-positive breast cancer.
- Cardiotoxicity is a known adverse effect of Trastuzumab, but right ventricular dysfunction is less commonly reported.
Purpose of the Study:
- To report the first case of Trastuzumab-induced right ventricular dysfunction and heart failure.
- To highlight the potential for TZ to cause specific cardiac adverse events.
Main Methods:
- Case report of a 46-year-old female patient with breast cancer treated with Trastuzumab.
- Clinical monitoring of cardiac function and response to drug discontinuation.
Main Results:
- The patient developed right heart failure and right ventricular dysfunction during Trastuzumab therapy.
- Cardiac function normalized after Trastuzumab was discontinued.
Conclusions:
- Trastuzumab can induce right ventricular dysfunction and cardiotoxicity.
- Discontinuation of Trastuzumab may lead to recovery of cardiac function.
- This case underscores the importance of monitoring cardiac health in patients receiving Trastuzumab.
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