Related Experiment Video
Updated: Apr 6, 2026
15:24
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
Published on: December 16, 2022
4.1K
From mice to humans: developments in cancer immunoediting
The Journal of Clinical Investigation
|August 5, 2015
Summary
The immune system
Area of Science:
- Immunology
- Oncology
Background:
- Cancer immunoediting describes how the immune system can suppress or promote tumor growth.
- While initially studied in mice, evidence for cancer immunoediting in human cancers is growing.
- CD8+ T cells are crucial in cancer immunoediting, especially in tumors with adaptive immune resistance.
Purpose of the Study:
- To review the characteristics of the adaptive immune resistance tumor microenvironment.
- To discuss the role of CD8+ T cells and other immune factors in cancer immunoediting.
- To explore the occurrence of cancer immunoediting in metastases versus primary tumors.
Main Methods:
- Review of existing data from mouse and human studies.
- Analysis of the adaptive immune resistance tumor microenvironment.
- Examination of factors influencing CD8+ T cell effector function.
Main Results:
- Adaptive immune resistance is a key feature of the tumor microenvironment.
- CD8+ T cells play a significant role in cancer immunoediting.
- Immunoediting dynamics may differ between primary tumors and metastases.
Conclusions:
- Cancer immunoediting is a critical process in human cancer development.
- Understanding the tumor microenvironment and immune cell roles is vital for cancer therapy.
- Further research is needed on immunoediting in metastatic disease.
More Related Videos
08:17A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
Published on: August 15, 2019
15.7K
05:15Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery
Published on: September 27, 2021
1.6K
Related Concept Videos
02:43Mouse Models of Cancer Study
6.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K
01:16In-vitro Mutagenesis
17.7K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
17.7K
02:23RNA Editing
10.2K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
10.2K