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Elevated Serum Fibroblast Growth Factor 21 Levels in Patients With Hyperthyroidism
Fangsen Xiao1, Mingzhu Lin1, Peiying Huang1
1Department of Endocrinology and Diabetes (F.X., M.L., P.H., J.Z., H.Z., Xi.L., S.Y., Xu.L.), the First Affiliated Hospital, Xiamen University, Xiamen 361003, China; Xiamen Diabetes Institute (M.L., X.Z., Xi.L., S.Y., Z.L., Xu.L.), Xiamen 361003, China; Shanghai Institute of Endocrinology and Metabolism (Xi.L.), Rui-Jin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China; Epidemiology Research Unit (Z.L.), The First Affiliated Hospital, Xiamen University, Xiamen 361003, China; and State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics (Z.L.), School of Public Health, Xiamen University, Xiamen 361005, China.
Serum fibroblast growth factor 21 (FGF21) levels are elevated in hyperthyroidism and decrease with treatment. FGF21 is independently associated with this metabolic disorder.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Fibroblast growth factor 21 (FGF21) is an endocrine hormone regulating glucose, lipid metabolism, and energy homeostasis.
- Animal studies suggest T3 regulates FGF21, but its role in human hyperthyroidism is unknown.
Purpose of the Study:
- To investigate serum FGF21 levels in hyperthyroid patients.
- To determine the association between serum FGF21 levels and hyperthyroidism.
Main Methods:
- A case-control study involving 119 hyperthyroid patients and 108 healthy controls.
- Serum FGF21 levels measured using ELISA.
- Analysis of FGF21 changes after 3 months of thionamide treatment in 41 patients.
Main Results:
- Hyperthyroid patients exhibited significantly elevated serum FGF21 levels compared to controls (P < .001).
- Thionamide treatment led to a marked decline in serum FGF21 levels (P < .001).
- Logistic regression identified FGF21, basal metabolic rate, LDL cholesterol, and ALT as significantly associated with hyperthyroidism; FGF21 remained independently associated (aOR=3.123, P=.010).
Conclusions:
- Serum FGF21 levels are elevated in hyperthyroidism.
- FGF21 levels decrease following treatment to euthyroidism.
- Serum FGF21 is an independent predictor of hyperthyroidism.
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