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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: November 1, 2010

[Three years of AIDS. Experience of the Curry Cabral Hospital with HIV infections (1985-1988)]

J A Monteiro, R Guimarães, J Albuquerue e Sousa

    Acta Medica Portuguesa
    |November 1, 1989
    PubMed

    Insights

    This study analyzed 90 human immunodeficiency virus (HIV) patients from 1985-1988, noting an increasing incidence and a high rate of heterosexual male infections. Key opportunistic infections and mortality rates in advanced HIV stages were documented.

    Area of Science:

    • Infectious Diseases
    • Epidemiology
    • Immunology

    Context:

    • Retrospective study of 90 human immunodeficiency virus (HIV) positive patients at Hospital Curry Cabral, Lisbon.
    • Data collected from 1985 to March 1988, encompassing HIV-1, HIV-2, and co-infections.
    • Analysis of patient demographics including sex, age, and risk factors.

    Purpose:

    • To describe the clinical characteristics and epidemiological trends of HIV patients.
    • To identify common opportunistic infections and their incidence within different disease stages.
    • To assess mortality rates and risk factors associated with HIV progression.

    Summary:

    • The study cohort comprised 90 patients (81 HIV-1, 6 HIV-2, 3 co-infected) with a mean age of 36.5 years, predominantly male (97.8%).
    • Key risk groups identified were homosexuals (64.4%), heterosexuals (21.1%), and intravenous drug users (7.7%).
    • High incidence of Kaposi's sarcoma (22%), Pneumocystis carinii pneumonia (55.6%), and Cryptococcosis (13.9%) was observed in the advanced Walter Reed stage 6 (WR6) group, with mortality rates of 31.3% for WR5 and 63.9% for WR6.

    Impact:

    • Highlights the increasing incidence of HIV infections and an unexpected rise in heterosexual male transmission.
    • Provides crucial data on the prevalence of specific opportunistic infections and their association with disease severity.
    • Establishes a baseline for understanding HIV/AIDS progression and outcomes in the pre-highly active antiretroviral therapy era.

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