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Related Experiment Video

Updated: Apr 6, 2026

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[HEMIHEPATECTOMY FOR RESECTABLE HEPATIC METASTASIS FROM COLORECTAL CANCER WITH POOR PROGNOSIS].

Yu I Patyutko, A G Kotelnikov, K G Mamontov

    Voprosy Onkologii
    |August 6, 2015
    PubMed
    Summary

    This study found that combined treatment with adjuvant systemic chemotherapy significantly improves 5-year survival for colorectal cancer liver metastases patients with poor prognoses. This approach offers better outcomes than surgery alone or other chemotherapy combinations.

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    Area of Science:

    • Oncology
    • Surgical Oncology
    • Gastroenterology

    Background:

    • Colorectal cancer liver metastases with poor prognostic factors present a significant treatment challenge.
    • Optimizing treatment strategies is crucial for improving survival in these patients.

    Purpose of the Study:

    • To evaluate the effectiveness of different combined treatment modalities for patients with resectable colorectal cancer liver metastases and poor prognoses.
    • To identify the optimal treatment strategy that maximizes long-term survival.

    Main Methods:

    • A cohort of 437 patients with resectable colorectal cancer liver metastases and adverse prognostic factors were analyzed.
    • Treatment groups included combined therapy (adjuvant systemic chemotherapy, perioperative systemic chemotherapy, perioperative regional chemotherapy), surgery alone, and systemic chemotherapy alone.
    • Outcomes, including complication rates, mortality, and 5-year survival, were compared across treatment groups.

    Main Results:

    • Combined treatment with adjuvant systemic chemotherapy resulted in a significantly higher 5-year survival rate (26 ± 4%) compared to surgery alone (17 ± 5%) and perioperative systemic chemotherapy (13 ± 5%).
    • Perioperative regional chemotherapy showed a trend towards better survival (20 ± 5%) but was not statistically significant compared to adjuvant systemic chemotherapy.
    • Complication rates (56%) and mortality (4%) were observed, with no significant differences in blood loss or postoperative outcomes between groups when bevacizumab was added to preoperative chemotherapy.

    Conclusions:

    • Combined treatment incorporating adjuvant systemic chemotherapy represents a superior strategy for improving survival in patients with resectable colorectal cancer liver metastases and poor prognoses.
    • For initially unresectable metastases, systemic chemotherapy should be the initial treatment, with surgery considered only after achieving resectability.