Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

149
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
149
Hypersensitivities01:30

Hypersensitivities

8.4K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.4K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

182
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
182
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

1.2K
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
1.2K
Allergic Reactions02:06

Allergic Reactions

33.7K
Overview
33.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and Solutions in Low-Biomass Respiratory Microbiome Profiling: A Workflow for Bronchoalveolar Lavage Fluid Sequencing in Guinea Pigs.

Physiological research·2026
Same author

The effect of stimulation and unloading of baroreceptors on cough in experimental conditions.

Respiratory physiology & neurobiology·2022
Same author

Various aspects of sex and gender bias in biomedical research.

Physiological research·2021
Same author

Legacy of Prof. Juraj Korpáš: International Impact of Slovak School of Experimental Respirology.

Physiological research·2020
Same author

Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration.

Physiological research·2020
Same author

Cough as a Cause and Consequence of Heart Dysfunction - Current State of Art.

Physiological research·2020
Same journal

Peach sublingual immunotherapy for lipid transfer protein syndrome.

Allergologia et immunopathologia·2026
Same journal

Gastrointestinal stenosis: an underrecognized complication of CARMIL2 deficiency.

Allergologia et immunopathologia·2026
Same journal

Peach sublingual immunotherapy for lipid transfer protein syndrome.

Allergologia et immunopathologia·2026
Same journal

Vitamin B12 allergy and desensitization.

Allergologia et immunopathologia·2026
Same journal

Chronic HBV infection, stemness pathways, and compromised immune surveillance in HCC development.

Allergologia et immunopathologia·2026
Same journal

Application of FeNO in the diagnostic and therapeutic algorithm of pediatric asthma: From chronic cough and wheeze to personalized management.

Allergologia et immunopathologia·2026
See all related articles

Related Experiment Video

Updated: Apr 6, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Histamine, histamine intoxication and intolerance.

E Kovacova-Hanuskova1, T Buday1, S Gavliakova1

  • 1Comenius University in Bratislava, Jessenius Faculty of Medicine, Department of Pathophysiology, Mala Hora, 036 01 Martin, Slovakia.

Allergologia Et Immunopathologia
|August 6, 2015
PubMed
Summary
This summary is machine-generated.

Histamine intolerance (HIT) occurs when the body cannot break down histamine from food, causing symptoms. A histamine-free diet and diamine oxidase supplements can improve quality of life for those with HIT.

Keywords:
Diamine oxidaseHistamineHistamine intoleranceScombroid poisoning

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K
An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
08:25

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

Published on: April 27, 2021

2.8K

Related Experiment Videos

Last Updated: Apr 6, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.1K
An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
08:25

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

Published on: April 27, 2021

2.8K

Area of Science:

  • Biochemistry
  • Immunology
  • Gastroenterology

Background:

  • Excessive histamine accumulation causes symptoms via H1-H4 receptors.
  • Histamine intoxication can occur in healthy individuals consuming high-histamine foods.
  • Histamine intolerance (HIT) involves insufficient histamine-degrading enzyme activity, leading to symptoms from normal histamine intake.

Purpose of the Study:

  • To elucidate the mechanisms and diagnostic challenges of histamine intolerance.
  • To highlight the clinical presentation and potential management strategies for HIT.

Main Methods:

  • Review of histamine metabolism and receptor interactions.
  • Analysis of clinical manifestations and differential diagnoses of HIT.
  • Evaluation of therapeutic approaches including dietary changes and enzyme supplementation.

Main Results:

  • HIT is characterized by reduced activity of histamine-degrading enzymes, leading to histamine overload.
  • Symptoms are non-specific and often misdiagnosed as allergies, mastocytosis, or psychosomatic disorders.
  • Diagnosis is challenging due to the varied clinical presentation.

Conclusions:

  • Accurate diagnosis of HIT is crucial for effective management.
  • A histamine-free diet is a primary therapeutic strategy.
  • Supplementation with diamine oxidase may aid in managing HIT symptoms and improving patient quality of life.