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Published on: March 28, 2025
Early acute ischaemic stroke in two patients with acute type B aortic dissection: an unusual complication
Abdullah AlGhamdi1, Saeed Alqahtani2, Meagan Ricketti3
1Pulmonary, Critical Care and Sleep Department, George Washington University, Washington DC, USA.
Insights
Early stroke is rare in type B aortic dissection. This study found cardioembolic events, linked to cardiomyopathy, caused early strokes in two type B patients, highlighting a new risk factor.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Cardiology
Background:
- Aortic dissection (AD) is a life-threatening cardiovascular condition.
- Type A AD involves the ascending aorta; Type B AD affects the descending aorta.
- Neurological complications, like ischemic stroke, are known but typically associated with Type A AD.
Observation:
- Early ischemic stroke is unusual in Type B AD.
- This report details two patients with Type B AD experiencing early ischemic strokes.
- Both patients had significant cardiomyopathies, with one exhibiting left ventricle thrombus.
Findings:
- The strokes in both patients were determined to be of cardioembolic origin.
- Cardiomyopathy and left ventricular thrombus were identified as potential sources for emboli.
- This suggests an alternative mechanism for early stroke in Type B AD.
Implications:
- Early stroke in Type B AD may stem from cardioembolic sources, not solely anatomical involvement.
- Screening for cardiomyopathies and cardiac thrombi is crucial in Type B AD patients presenting with stroke.
- This finding broadens the understanding of stroke pathogenesis in aortic dissection.
Abstract:
Aortic thoracic dissection (AD) is a serious cardiovascular disease. According to the Stanford classification; type A involves the ascending aorta and type B the descending distal to the left subclavian artery. Neurological complications secondary to AD are devastating. Ischaemic stroke and hypoxic encephalopathy are early-recognised complications of type A as the arch vessels can be involved AD. Although, late ischaemic stroke had been reported in 1.4-5% of patients with type B dissection, early stroke is very unusual as it cannot be simply explained by AD anatomical pathogenesis. We report two patients who presented with type B AD complicated by early ischaemic strokes. Work-up revealed significant cardiomyopathies in both patients but with left ventricle thrombus in one. In both patients the strokes were felt to be of cardioembolic origin.
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