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Published on: August 1, 2018
Peptide δ-Turn: Literature Survey and Recent Progress
Claudio Toniolo1, Marco Crisma2, Alessandro Moretto2
1ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, 35131 Padova (Italy). claudio.toniolo@unipd.it.
Abstract:
Among the various types of α-peptide folding motifs, δ-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the δ-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.
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