Related Experiment Video
Updated: Apr 5, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Genes and Environment as Predisposing Factors in Autoimmunity: Acceleration of Spontaneous Thyroiditis by Dietary
Panayota Kolypetri1, Justin King, Mani Larijani
1Division of Biomedical Sciences, Memorial University of Newfoundland , St. John's, NL , Canada.
Abstract:
In the field of autoimmune thyroiditis, NOD.H2h4 mice have attracted significant and increasing attention since they not only develop spontaneous disease but they present thyroiditis with accelerated incidence and severity if they ingest iodide through their drinking water. This animal model highlights the interplay between genetic and dietary factors in the triggering of autoimmune disease and offers new opportunities to study immunoregulatory parameters influenced by both genes and environment. Here, we review experimental findings with this mouse model of thyroiditis.
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