Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recursive descent probabilities for rare recessive lethals.

E A Thompson1, K Morgan

  • 1Department of Statistics GN-22, University of Washington, Seattle 98195.

Annals of Human Genetics
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Spatially defined intratumoral immune biomarkers predict recurrent versus second primary tumors in non-small cell lung cancer.

Precision clinical medicine·2025
Same journal

Utility of Urine-Derived Cells for Characterizing Aberrant Splicing Caused by a Novel Deep Intronic L1CAM Variant.

Annals of human genetics·2026
Same journal

Distribution of HLA-DRB1 Alleles and Genotypes With Respect to Plasma Anti-SARS-CoV-2 IgG Titres Among COVID-19-Vaccinated Bangladeshi Adults.

Annals of human genetics·2026
Same journal

FIGLA Novel Variant c.385-9G>A Affects RNA Splicing in a Minigene Assay.

Annals of human genetics·2026
Same journal

Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.

Annals of human genetics·2026
Same journal

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

Annals of human genetics·2026
Same journal

A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency.

Annals of human genetics·2026
See all related articles

We improved methods for tracing rare genetic traits in large families by accounting for lethal recessive conditions. This helps understand disease ancestry more accurately in complex human pedigrees.

Area of Science:

  • Population Genetics
  • Genetic Epidemiology
  • Bioinformatics

Background:

  • Traditional descent probability calculations for rare alleles in large genealogies overlook crucial genetic information.
  • Existing methods do not account for the impact of lethal recessive traits on ancestral possibilities.
  • Understanding the ancestry of rare genetic disorders is vital for genetic counseling and research.

Purpose of the Study:

  • To enhance descent probability computations by integrating information about lethal recessive traits.
  • To develop a more accurate method for evaluating the ancestry of rare alleles in complex pedigrees.
  • To apply this refined methodology to real-world genetic data from a specific population.

Main Methods:

  • Modified recursive descent probability calculations to incorporate constraints imposed by lethal recessive conditions.

Related Experiment Videos

  • Applied the enhanced methodology to analyze two distinct rare recessive traits.
  • Utilized a complex Hutterite (Lehrerleut) genealogy for case study analysis.

    • Main Results:

    • The modified computations provide a more informed assessment of allele ancestry by excluding impossible ancestral states.
    • Demonstrated the practical application of the method in a detailed Hutterite family tree.
    • The approach successfully identified potential ancestral origins for the studied rare recessive traits.

    Conclusions:

    • Incorporating lethal recessive trait information significantly improves the accuracy of ancestry evaluation for rare alleles.
    • This refined method offers a powerful tool for studying genetic disorders in populations with complex family structures.
    • The findings have implications for understanding the segregation of genetic diseases and informing genetic research.