Related Experiment Video
Updated: Apr 5, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Sevelamer Hydrochloride for Tumor Lysis Syndrome-related Hyperphosphatemia
1Department of Pediatrics, Kasturba Medical College Hospital, Mangalore (Manipal University), Karnataka, India. Correspondence to: Dr Harsha Prasada L, Department of Pediatrics, Kasturba Medical College Hospital, Mangalore 575 001, Karnataka. Harsha.pl@manipal.edu.
Background:
Tumour lysis syndrome is associated with high levels of uric acid, phosphate and potassium along with low levels of calcium and abnormal renal function. Sevelamer, an oral phosphate-binder is used in the treatment of hyperphosphatemia in children and adults on hemodialysis.
Case Characteristics:
Two children with T-cell acute lymphoblastic leukemia who presented with a high tumour load and developed tumour lysis syndrome.
Observation:
Both children received Rasburicase and Sevelamer hydrochloride. The serum phosphate reduced to normal levels within 24-48 hrs of initiation of sevelamer hydrochloride.
Message:
Sevelamer appears to be an effective treatment for hyperphosphatemia associated with tumour lysis syndrome.
Related Concept Videos
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi III: Medical Management
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Urinary Tract Calculi VI: Surgical Management
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

