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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Updated: Apr 5, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
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[Can we prevent pain becoming chronic?].

Nora Hagelberg, Maija Haanpää

    Duodecim; Laaketieteellinen Aikakauskirja
    |August 7, 2015
    PubMed
    Summary

    Effective chronic pain prevention involves managing acute pain, identifying risk factors early, and using a multidisciplinary approach. Strategies like vaccination for postherpetic neuralgia and specific medications show promise in preventing chronic pain conditions.

    Area of Science:

    • Pain management and prevention strategies.
    • Neurology and pain research.

    Context:

    • Acute pain requires effective management to prevent chronification.
    • Identifying individuals at risk for chronic pain is crucial.
    • Postherpetic neuralgia and prolonged postoperative pain present distinct prevention challenges.

    Purpose:

    • To outline key strategies for preventing acute pain from becoming chronic.
    • To review current evidence on preventing specific pain conditions like postherpetic neuralgia and prolonged postoperative pain.
    • To highlight the role of multidisciplinary approaches in managing and preventing lower back pain recurrence.

    Summary:

    • Central to preventing chronic pain are optimal acute pain management, early risk factor identification, and multidisciplinary collaboration.

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  • Postherpetic neuralgia prevention may involve vaccines and medication, while prolonged postoperative pain prevention shows limited evidence for local anesthetics and ketamine.
  • Multidisciplinary interventions are effective in preventing the prolongation and recurrence of lower back pain, particularly in high-risk individuals.

    • Impact:

    • Provides a framework for clinicians to implement evidence-based strategies for chronic pain prevention.
    • Informs the development of targeted interventions for specific pain syndromes.
    • Emphasizes the importance of a holistic, team-based approach in pain management and rehabilitation.