Related Experiment Video
Updated: Apr 5, 2026
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
Contribution of CD24 polymorphisms to autoimmune disease: A meta-analysis
Jihae Baek1, Soowon Kang1, Hyeyoung Byeon1
1College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Purpose:
To determine the relationship between two CD24 polymorphisms, rs8734/rs52812045 and rs3838646, and autoimmune disease.
Design:
Meta-analysis.
Methods:
The Medline, EMBASE, Web of Science, and Cochrane Library databases were searched for studies reporting the association between CD24 polymorphisms and autoimmune disease. Two of the authors selected eligible studies and extracted and analyzed the data independently.
Results:
Compared with carriers of the C allele (CC, CT, CT+CC), individuals homozygous for the T allele (TT) and heterozygous (CT+TT) at rs8734/rs52812045 have a higher incidence of autoimmune disease, whereas rs3838646 is not associated with autoimmune disease. Subgroup analysis found an increased risk of multiple sclerosis with the TT vs. CC, TT vs. CT, and TT vs. CC+CT alleles.
Conclusion:
The CD24 polymorphism rs8734/rs52812045 contributes to the development of autoimmune disease.
More Related Videos
Related Concept Videos
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:11Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...