[Amiodarone neurotoxicity. Report of 3 cases]

Three patients were investigated due to neurological symptoms induced by amiodarone used to treat refractory cardiac arrhythmia. Chronic polineuritis was found in two and dyskinesia in one. The light and electromicroscopical studies (cases 1 and 2) of a N. Suralis (neuropathic cases) display a loss of large myelinated fibers and marked reduced unmyelinated axons associated with osmiophilic inclusions in Schwann cells and endothelial venulae. The EEG was abnormal in the case of dyskinesia (n.3). The interruption of amiodarone improved the neurological symptoms.