Experimental studies on effects of long-term ethanol administration on meprobamate elimination from blood

When rabbits were administered different amounts of ethanol during 25 and 50 days, the elimination of meprobamate from blood was not accelerated at daily ethanol dose of 0.4g/kg. The elimination was accelerated a little at daily ethanol dose of 0.8g/kg and markedly accelerated at the dose of 1.6g/kg. However, it was not accelerated furthermore at the dose of 2.4g/kg. Thus, accelerative effect of long-term ethanol administration on meprobamate metabolism may be greatly related to ethanol dosage and it is considered that the accelerative effects reach maximum at blood ethanol concentrations more than 1mg/ml. Also, elimination of meprobamate from brain in rats was fairly accelerated by long-term ethanol administration at the daily dose of 0.4g.