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Vinpocetine pharmacokinetics in elderly subjects
R Grandt1, H Beitinger, R Schaltenbrand
1Research and Development, Thiemann Arzneimittel GmbH, Waltrop, Fed. Rep. of Germany.
Arzneimittel-Forschung
|December 1, 1989
Summary
Vinpocetine (Eusenium) pharmacokinetics in elderly volunteers showed 6.7% absolute bioavailability via oral administration. Drug levels were consistent with existing literature, indicating no significant age-related kinetic deviations for apovincaminic acid.
Area of Science:
- Pharmacology
- Geriatric Medicine
- Drug Metabolism
Background:
- Vinpocetine (Eusenium) is a drug used for cerebrovascular and cognitive disorders.
- Understanding its pharmacokinetic profile in elderly populations is crucial for safe and effective dosing.
Purpose of the Study:
- To investigate the pharmacokinetics of vinpocetine in healthy elderly volunteers.
- To compare oral and intravenous administration routes.
- To assess the bioavailability and kinetic profile of vinpocetine and its metabolite, apovincaminic acid.
Main Methods:
- 20 healthy elderly volunteers participated.
- Plasma drug levels were measured after oral (20 mg) and intravenous (10 mg) administration.
- Key pharmacokinetic parameters including AUC, Cmax, and tmax were calculated.
Main Results:
- Oral administration yielded an absolute bioavailability of 6.7% for vinpocetine.
- AUC, Cmax, and tmax values were determined for both vinpocetine and apovincaminic acid.
- Intravenous infusion data provided AUC values for both compounds.
Conclusions:
- Vinpocetine exhibits a defined pharmacokinetic profile in elderly individuals.
- The study's findings align with existing literature, suggesting no significant age-related differences in apovincaminic acid kinetics.
- Results support the established use of vinpocetine in geriatric populations.