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Published on: March 18, 2020
Supratracheal laryngectomy: current indications and contraindications
G Succo1, M Bussi2, L Presutti3
1Otolaryngology Service, Oncology Department, "San Luigi Gonzaga" Hospital, University of Turin, Italy;
Supratracheal partial laryngectomy (STPL) offers effective oncological and functional outcomes for intermediate/advanced laryngeal cancer with sub-glottic extension. This function-sparing surgery demonstrates good survival and organ preservation rates, particularly for earlier stages.
Area of Science:
- Otolaryngology
- Surgical Oncology
- Laryngeal Cancer Research
Background:
- Intermediate/advanced laryngeal cancer poses challenges for disease control and organ preservation.
- Supratracheal partial laryngectomy (STPL) is a function-sparing technique for laryngeal cancer with sub-glottic extension.
Purpose of the Study:
- To evaluate the indications, contraindications, and long-term oncological and functional outcomes of STPL.
- To analyze clinical results in patients with laryngeal cancer staged pT2-pT4a undergoing STPL.
Main Methods:
- Multi-institutional study analyzing clinical outcomes of 142 patients with laryngeal cancer (pT2-pT4a) who underwent STPL.
- Evaluation of five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), loco-regional control (LRC), laryngeal function preservation (LFP), and laryngectomy-free survival (LFS).
Main Results:
- Five-year survival rates varied by stage: pT2 (OS 71.4%, DSS 95.2%), pT3 (OS 85.3%, DSS 91.1%), and pT4a (OS 73.2%, DSS 88.1%).
- DFS and LRC were significantly impacted by pT4a staging. LFP and LFS were affected by pT staging and age (≥65 years).
- Common sites of local failure included the tracheal passage, posterior commissure, contralateral cricoarytenoid unit, and outer larynx surface.
Conclusions:
- STPL is an effective surgical option for glottic or transglottic tumors with sub-glottic extension, offering favorable prognostic and functional results.
- Careful patient selection based on local and general factors is crucial for optimizing outcomes.
- STPL contributes to laryngeal function preservation and improved survival in selected laryngeal cancer patients.
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