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Updated: Apr 5, 2026

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
Umbilical Cord Tissue-Derived Cells as Therapeutic Agents
Olga Maslova1, Miroslav Novak2, Peter Kruzliak2
1National Taras Shevchenko University of Kyiv, Kyiv, Ukraine ; Hemafund Ltd., Lisozakhysna Street 5, Kyiv, Ukraine.
This review examines the clinical utility of umbilical cord (UC)-derived stem cells (SCs), highlighting their advantages and addressing controversial issues for therapeutic applications.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Tissue Engineering
Background:
- Umbilical cord (UC)-derived cells are a subject of intense research due to their stem cell (SC) characteristics.
- These cells offer distinct advantages over other stem cell sources.
- Understanding UC topography's influence on cell properties is crucial.
Purpose of the Study:
- To critically evaluate the clinical utility of cells derived from umbilical cord (UC) tissue.
- To discuss controversial aspects surrounding the application of UC-derived stem cells.
- To explore future perspectives for UC-derived cell therapies.
Main Methods:
- Literature review focusing on stem cell characteristics and clinical applications.
- Analysis of existing research on UC-derived cell isolation, culturing, and cryopreservation.
- Discussion of Good Manufacturing Practice (GMP) adaptation for UC-derived cell processing.
Main Results:
- UC-derived cells possess unique advantages for therapeutic use.
- Several controversial issues regarding their clinical utility require further investigation.
- The topography of UC tissue influences cell characteristics.
Conclusions:
- UC-derived stem cells show significant therapeutic potential but face challenges.
- Standardization of isolation, culturing, and cryopreservation under GMP conditions is essential.
- Further research is needed to resolve controversies and advance clinical applications.
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