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Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy.

Radouil Tzekov¹, Brian Madow¹

¹Department of Ophthalmology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, P.O. Box MDC 21, Tampa, FL 33612, USA.

Journal of Ophthalmology

|August 7, 2015

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Birdshot chorioretinopathy (BSCR) monitoring relies on visual electrophysiology. The full-field ERG light-adapted 30 Hz flicker peak time is emerging as a sensitive parameter for assessing treatment efficacy in BSCR.

Area of Science:

Ophthalmology
Immunology
Neuroscience

Background:

Birdshot chorioretinopathy (BSCR) is a rare autoimmune posterior uveitis.
Untreated BSCR can lead to vision loss and sight-threatening complications.

Purpose of the Study:

To systematically review visual electrophysiology studies for monitoring BSCR progression and treatment efficacy.
To identify the most sensitive electrophysiological parameters for BSCR assessment.

Main Methods:

Systematic literature search focusing on electroretinography (ERG), electrooculography (EOG), and visual evoked potentials (VEP) in BSCR patients.
Analysis of various electrophysiological parameters reported in the literature.

Main Results:

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Multiple electrophysiological parameters, including EOG Arden's ratio and multifocal ERG response densities, are affected in BSCR.

The full-field ERG light-adapted 30 Hz flicker peak time is recognized as a highly sensitive parameter.

This parameter is increasingly used in clinical trials and practice for evaluating drug efficacy and guiding treatment.

Conclusions:

While several electrophysiological methods exist, the full-field ERG light-adapted 30 Hz flicker peak time shows significant promise for BSCR monitoring.
A lack of standardized, longitudinal, multicenter studies hinders direct comparison of methods.
Further research is needed to systematically evaluate and compare different electrophysiological parameters to optimize BSCR diagnosis and treatment.