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[Hemorheological and coagulation aspects in plasmacytoma]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|October 1, 1989
Summary
Monoclonal gammopathy can increase blood viscosity. Plasmapheresis effectively reduced plasma and serum viscosity in patients with IgA monoclonal gammopathy, improving rheological features.
Area of Science:
- Hematology
- Rheology
- Immunology
Context:
- Monoclonal gammopathy is characterized by the overproduction of monoclonal immunoglobulin (paraprotein).
- Elevated plasma and serum viscosity are common complications, impacting blood flow and coagulation.
- This study investigates rheological and coagulative changes in patients with different paraprotein classes.
Purpose:
- To characterize the rheological and coagulative features in patients with monoclonal gammopathy.
- To evaluate the efficacy of plasma volume plasmapheresis in managing increased viscosity associated with IgA monoclonal paraproteinaemia.
Summary:
- Seven patients with monoclonal gammopathy (IgA, IgM, or IgG) were studied.
- All patients exhibited increased plasma and serum viscosity.
- Four patients with IgA monoclonal paraproteinaemia underwent plasmapheresis, which effectively reduced viscosity.
Impact:
- Plasmapheresis is a viable therapeutic option for reducing viscosity in monoclonal gammopathy.
- Understanding rheological changes is crucial for managing patients with paraproteinaemia.
- This study highlights the clinical utility of plasmapheresis in improving blood viscosity in specific monoclonal gammopathy cases.