Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

804
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
804
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

80
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
80
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

378
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
378
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

129
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
129
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

91
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
91
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

484
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
484

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis C Screening Among Persons Experiencing Homelessness in the Emergency Department: A Secondary Analysis of the Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Screening Trial.

Annals of emergency medicine·2026
Same author

A Comprehensive Evaluation of Mobility: Validation of the Functional Ambulation and Stair Test in Older Adults.

Journal of clinical medicine·2026
Same author

Continuous glucose monitoring for cystic fibrosis-related diabetes: impact on quality of life and glycaemic control.

Diabetes research and clinical practice·2026
Same author

Creating and Piloting a Spanish-Language Version of the Clinical Opiate Withdrawal Scale (COWS): La Escala Clínica de Síndrome Abstinencia de Opiáceos (ECAO).

Substance abuse and rehabilitation·2026
Same author

Identification, synthesis, and characterization of a unique N-glucuronide of an acid metabolite of camizestrant (AZD9833) in humans.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Gut Microbiota Mediate the Metabolism of Colonic Prostaglandins.

Research square·2026
Same journal

Analyses of gender disparities in receipt of bystander cardiopulmonary resuscitation after out-of-hospital cardiac arrests by patient's age group and bystander category.

Resuscitation·2026
Same journal

A scoping review of Support Interventions for Bystanders involved in Out-of-Hospital Cardiac Arrest.

Resuscitation·2026
Same journal

Sedation Early After Return of Spontaneous Circulation and During Pre-Hospital Transport After Out-Of-Hospital Cardiac Arrest: Retrospective Analysis of the AfterROSC1 & 2 Database.

Resuscitation·2026
Same journal

Volume-controlled mechanical ventilation during cardiopulmonary resuscitation: A systematic review and meta-analysis.

Resuscitation·2026
Same journal

Number of community first responders needed for quick response times to cardiac arrest: a nationwide study.

Resuscitation·2026
Same journal

Device damage and malfunction during dual defibrillation or dual electrical cardioversion: a scoping review.

Resuscitation·2026
See all related articles

Related Experiment Video

Updated: Apr 5, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.6K

Color-coded prefilled medication syringes decrease time to delivery and dosing errors in simulated prehospital

Allen D Stevens1, Caleb Hernandez2, Seth Jones3

  • 1Department of Medicine, National Jewish Health, Denver, CO, USA; Division of Emergency Medical Services, Platte Valley Medical Center, Brighton, CO, USA.

Resuscitation
|August 7, 2015
PubMed
Summary
This summary is machine-generated.

Novel color-coded prefilled syringes significantly reduced critical medication dosing errors in simulated pediatric resuscitations. This innovation also decreased medication administration time for paramedics.

Keywords:
Cardiac arrestDosing errorEmergency medical servicesMedication administrationPediatricsSimulation

More Related Videos

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.6K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

8.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.6K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.6K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

8.1K

Area of Science:

  • Emergency Medicine
  • Pediatric Resuscitation
  • Medication Safety

Background:

  • Medication dosing errors are frequent, especially in pediatrics, posing life-threatening risks.
  • Weight-based dosing calculations are common in pediatric care.
  • Novel medication delivery systems are a national healthcare priority to reduce errors.

Purpose of the Study:

  • To evaluate novel, prefilled, color-coded medication syringes.
  • To compare these syringes against conventional administration methods.
  • To assess their impact in simulated prehospital pediatric resuscitation scenarios.

Main Methods:

  • Prospective, block-randomized, cross-over study design.
  • 10 paramedics managed two simulated pediatric arrests each (intervention vs. control).
  • Video recording and blinded, independent reviewer data extraction.

Main Results:

  • Median time to medication delivery was faster with color-coded syringes (34s vs. 42s).
  • Critical dosing errors occurred in 39% of conventional administrations (24/62 doses).
  • Zero critical dosing errors occurred with prefilled syringes (0/59 doses).

Conclusions:

  • Color-coded, prefilled syringes significantly reduced critical dosing errors.
  • These novel syringes decreased medication administration time.
  • The system shows promise for improving pediatric resuscitation safety in prehospital settings.