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Updated: Apr 5, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Functionalization of Platinum Complexes for Biomedical Applications
Xiaoyong Wang1,2, Xiaohui Wang3,4, Zijian Guo3,2
1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University , Nanjing 210023, P. R. China.
Functionalizing platinum complexes enhances their anticancer efficacy by improving tumor targeting and reducing toxicity. This review explores strategies for targeted drug delivery and theranostic applications, showcasing new potential for platinum-based therapies.
Area of Science:
- * Medicinal Chemistry
- * Nanotechnology
- * Oncology
Background:
- * Platinum-based drugs are vital chemotherapy agents but face challenges like systemic toxicity and drug resistance.
- * Current platinum drugs have largely unknown pharmacokinetics, limiting their therapeutic optimization.
- * Functionalization of platinum complexes is a growing area of research to address these limitations.
Purpose of the Study:
- * To review strategies for functionalizing platinum complexes for improved anticancer therapy.
- * To highlight applications in targeted drug delivery, theranostics, and other biomedical areas.
- * To assess the opportunities and challenges in developing advanced platinum-based agents.
Main Methods:
- * Review of literature on functionalized platinum complexes published since 2010.
- * Categorization of functionalization strategies based on targeting mechanisms (active/passive) and applications.
- * Analysis of representative examples of targeted delivery systems, anticancer conjugates, theranostic agents, and anti-Alzheimer's compounds.
Main Results:
- * Functionalization strategies include conjugation with bisphosphonates, peptides, ligands, polymers, nanoparticles, imaging agents, and photosensitizers.
- * Active targeting utilizes bisphosphonates, peptides, and ligands; passive targeting uses polymers and nanoparticles.
- * Applications span targeted delivery, theranostics (imaging and therapy), and treatment of conditions like Alzheimer's disease.
Conclusions:
- * Functionalized platinum complexes offer significant potential for enhanced tumor selectivity, reduced systemic toxicity, and overcoming drug resistance.
- * Targeted drug delivery and theranostic applications represent key advancements in platinum-based chemotherapy.
- * Further research and assessment of functionalization strategies are needed to overcome existing shortcomings and realize the full potential of these agents.
