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Optical Trapping of Nanoparticles
Published on: January 15, 2013
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Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles
Brandon Redding1, Mark Schwab2, Yong-le Pan3
1U.S. Army Research Laboratory, 2800 Powder Mill Road, Adelphi, MD 20783, USA. redding.brandon@gmail.com.
Sensors (Basel, Switzerland)
|August 7, 2015
Summary
Optical trapping combined with Raman spectroscopy enables detailed study of individual biological micro-particles. This powerful technique allows for specific identification and analysis of particle composition in air and liquid.
Area of Science:
- Biophysics
- Spectroscopy
- Optical trapping
Background:
- Raman scattering is inefficient for studying individual micro-particles.
- Optical trapping can isolate and manipulate micro-particles.
Purpose of the Study:
- To review the integration of optical trapping and Raman spectroscopy.
- To highlight applications and future directions for studying biological micro-particles.
Main Methods:
- Combining optical trapping with Raman spectroscopy.
- Analyzing individual biological particles in air and liquid.
Main Results:
- Overcomes limitations of Raman scattering inefficiency.
- Enables high-specificity particle identification.
- Allows longitudinal studies of particle composition.
- Characterizes heterogeneity of particle populations.
Conclusions:
- The integrated technique offers unique measurement capabilities.
- Promising applications exist for biological particle analysis.
- Further research directions are identified.
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