Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.9K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.9K
Tumor Progression02:07

Tumor Progression

3.6K
3.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.2K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.1K
3.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.4K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix.

The Journal of infectious diseases·2026
Same author

Neural cues differentially modulate colorectal cancer cell behavior depending on patients' genomic background.

iScience·2026
Same author

The Rising Burden of Early-Onset Cancer: Challenges and Opportunities.

Cancer discovery·2026
Same author

WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer.

EMBO molecular medicine·2026
Same author

Mismatch Repair-Proficient Colorectal Cancer can evade Immune Surveillance Through an Intrinsic Suppressive Program.

Cancer discovery·2026
Same author

Pharmacological inhibition of PMS2 induces MMR deficiency and response to immune checkpoint blockade.

Cancer discovery·2026

Related Experiment Video

Updated: Apr 5, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

19.3K

Toward understanding and exploiting tumor heterogeneity.

Ash A Alizadeh1, Victoria Aranda2, Alberto Bardelli3

  • 11] Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. [2] Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. [3] Cancer Institute, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Nature Medicine
|August 7, 2015
PubMed
Summary

Understanding tumor heterogeneity is crucial for cancer research. This study identifies key challenges and proposes solutions to advance translational research in tumor evolution and clinical progression.

More Related Videos

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.4K
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.2K

Related Experiment Videos

Last Updated: Apr 5, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

19.3K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.4K
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.2K

Area of Science:

  • Oncology
  • Genetics
  • Biotechnology

Background:

  • Tumor heterogeneity, encompassing genetic and epigenetic variations, is an emerging area of cancer research.
  • The impact of tumor heterogeneity on cancer evolution, clinical progression, and the role of environmental factors remains largely unknown.
  • Translational research in tumor heterogeneity faces significant obstacles.

Purpose of the Study:

  • To identify critical obstacles hindering advancements in translational research for tumor heterogeneity.
  • To establish key questions regarding the influence of genetic, epigenetic, and environmental factors on tumor heterogeneity.
  • To propose potential solutions and strategies to overcome identified challenges.

Main Methods:

  • A focused meeting organized by Nature Medicine, Nature Biotechnology, and the Volkswagen Foundation.
  • Discussion and identification of key research questions and obstacles in tumor heterogeneity.
  • Collaborative development of potential solutions and future research directions.

Main Results:

  • Key challenges in understanding and targeting tumor heterogeneity were elucidated.
  • Critical questions concerning the drivers and consequences of tumor heterogeneity were defined.
  • Potential strategies to advance translational research in this field were proposed.

Conclusions:

  • Addressing tumor heterogeneity requires overcoming specific research and translational hurdles.
  • Further investigation into genetic, epigenetic, and environmental influences is essential.
  • Collaborative efforts are needed to translate fundamental discoveries into clinical applications for cancer patients.