Related Experiment Videos
Thyroid disease in pustulosis palmoplantaris
T Agner1, J H Sindrup, M Høier-Madsen
1Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
The British Journal of Dermatology
|October 1, 1989
Summary
Palmar and plantar pustulosis (PPP) patients show a higher incidence of thyroid disease, including goiter and thyroid autoantibodies. This suggests a potential link between PPP and autoimmune thyroid conditions, warranting further investigation.
Area of Science:
- Endocrinology
- Dermatology
- Autoimmunity
Background:
- Palmar and plantar pustulosis (PPP) is a chronic inflammatory skin condition.
- Previous reports suggest an association between PPP and thyroid autoimmunity.
Purpose of the Study:
- To investigate the frequency and types of thyroid disease in patients with palmar and plantar pustulosis.
- To compare thyroid disease prevalence in PPP patients versus a control group.
Main Methods:
- A case-control study involving 32 patients with PPP and a matched control group.
- Assessment of thyroid disease, including goiter and thyroid autoantibodies, and thyroid hormone levels.
Main Results:
- Thyroid disease was found in 53% of PPP patients, compared to 16% in controls.
- 14 PPP patients had enlarged thyroids (goiter), and 6 had thyroid autoantibodies.
- A decrease in thyroid hormone levels was observed in PPP patients.
Conclusions:
- There is an increased incidence of goiter and thyroid autoantibodies in patients with palmar and plantar pustulosis.
- The findings suggest a significant association between PPP and autoimmune thyroid disease.
- Further research is recommended to elucidate the underlying mechanisms connecting these conditions.