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siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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Basal Autophagy Is Required for Herpes simplex Virus-2 Infection

Abraam M Yakoub1, Deepak Shukla1

  • 11] Department of Microbiology and Immunology, University of Illinois, Chicago, IL USA, 60612 [2] Department of Ophthalmology and Visual Sciences, University of Illinois Medical Center, Chicago, IL USA, 60612.

Scientific Reports
|August 8, 2015
PubMed
Summary

Basal autophagy, unlike induced autophagy, is essential for Herpes simplex virus-2 (HSV-2) replication. Suppressing basal autophagy significantly reduces HSV-2 infection, highlighting its critical role in supporting viral proliferation.

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