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Connecting Myokines and Metabolism
Rexford S Ahima1, Hyeong Kyu Park2
1Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. ahima@mail.med.upenn.edu.
Endocrinology and Metabolism (Seoul, Korea)
|August 8, 2015
Summary
Skeletal muscle acts as an endocrine organ, releasing myokines (hormones) that regulate metabolism and inflammation. These myokines are potential therapeutic targets for diseases like obesity and diabetes.
Area of Science:
- Endocrinology
- Metabolic research
- Exercise science
Background:
- Skeletal muscle, the largest organ in non-obese individuals, functions as an endocrine organ.
- It secretes myokines, hormones that facilitate inter-organ communication.
- These myokines play crucial roles in regulating physiological processes.
Purpose of the Study:
- To review recent advancements in myokine biology.
- To assess the therapeutic potential of myokines.
Main Methods:
- Literature review of current research on myokines.
- Analysis of myokine functions in metabolism and inflammation.
Main Results:
- Myokines influence muscle mass, myofiber type, and energy homeostasis.
- They impact glucose and lipid metabolism and inflammatory responses.
- Dysregulation of myokines is implicated in obesity and diabetes pathogenesis.
Conclusions:
- Myokines are key mediators of skeletal muscle's endocrine function.
- Understanding myokine biology offers insights into metabolic diseases.
- Myokines represent promising targets for novel therapeutic strategies.
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