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Subclinical Hypothyroidism and Cardiovascular Disease

Sunghwan Suh1, Duk Kyu Kim2

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A Medical Center, Dong-A University College of Medicine, Busan, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|August 8, 2015
PubMed

Insights

Subclinical hypothyroidism (SCH), a common thyroid disorder, is linked to cardiovascular risks. Further research is needed to confirm if levothyroxine treatment effectively reduces these risks.

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Background:

  • Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine.
  • Thyroid hormones significantly influence cardiovascular (CV) function and health.
  • The CV implications of SCH are a growing area of research interest.

Purpose of the Study:

  • To review the association between SCH and cardiovascular risk factors.
  • To explore the potential of SCH as a modifiable CV disease risk factor.
  • To highlight the need for further clinical trials on SCH treatment.

Main Methods:

  • Literature review of studies investigating SCH and cardiovascular outcomes.
  • Analysis of evidence linking SCH to traditional CV risk factors.
  • Examination of associations between SCH, metabolic syndrome, and heart failure.

Main Results:

  • SCH is associated with adverse CV risk factors, including hypertension, dyslipidemia, and atherosclerosis.
  • Evidence suggests a correlation between SCH and metabolic syndrome and heart failure.
  • SCH may represent a potentially modifiable risk factor for CV disease and mortality.

Conclusions:

  • SCH is linked to increased cardiovascular risk.
  • Levothyroxine therapy may offer benefits, but requires validation.
  • Large-scale, powered clinical trials are essential to determine optimal management strategies for SCH.

Keywords:
Cardiovascular diseasesSubclinical hypothyroidism

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