Related Experiment Video
Updated: Apr 5, 2026

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence
Published on: March 9, 2015
A Practical Guide for the Formulation of Propositions in the Bayesian Approach to DNA Evidence Interpretation in an
Simone Gittelson1, Tim Kalafut2, Steven Myers3
1Department of Biostatistics, University of Washington, Seattle, WA, 98195.
Abstract:
The interpretation of complex DNA profiles is facilitated by a Bayesian approach. This approach requires the development of a pair of propositions: one aligned to the prosecution case and one to the defense case. This note explores the issue of proposition setting in an adversarial environment by a series of examples. A set of guidelines generalize how to formulate propositions when there is a single person of interest and when there are multiple individuals of interest. Additional explanations cover how to handle multiple defense propositions, relatives, and the transition from subsource level to activity level propositions. The propositions depend on case information and the allegations of each of the parties. The prosecution proposition is usually known. The authors suggest that a sensible proposition is selected for the defense that is consistent with their stance, if available, and consistent with a realistic defense if their position is not known.
Related Concept Videos
DNA as a Genetic Template
DNA as a Genetic Template
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
DNA Base Pairing
DNA Base Pairing
Base-pairing and DNA Repair

