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Updated: Apr 5, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Metabolomics of cocaine: implications in toxicity
Ricardo Jorge Dinis-Oliveira1,2,3
1a Department of Sciences , IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Advanced Institute of Health Sciences - North (ISCS-N) , CESPU , CRL , Gandra , Portugal .
Abstract:
Cocaine is the most commonly used illicit drug among those seeking care in Emergency Departments or drug detoxification centers. Cocaine, chemically known as benzoylmethylecgonine, is a naturally occurring substance found in the leaves of the Erythroxylum coca plant. The pharmacokinetics of cocaine is dependent on multiple factors, such as physical/chemical form, route of administration, genetics and concurrent consumption of alcohol. This review aims to discuss metabolomics of cocaine, namely by presenting all known metabolites of cocaine and their roles in the cocaine-mediated toxic effects.
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