[Circulating antitrophoblast antibodies in normal pregnancy and in EPH gestosis]

Antitrophoblastic antibodies were assessed by the bond with the antigen of syncytiotrophoblastic membranes according to Davies (ELISA system) in 17 nulligravidae, in 33 men and 70 pregnant women. The pregnancy was normal in 27 women in the Ist and in 32 in the IIIrd trimester, 11 women had signs of EPH gestosis. The incidence of antitrophoblastic antibodies rises significantly with the period of gestation, in women with toxaemia the values are reduced as compared with the group in the third trimester. The authors did not find a relationship between the values of these antibodies and the concurrently assessed level of immunoglobulin IgG, IgA and IgM. Possibilities of the development of toxic immunocomplexes during EPH toxaemia are discussed.