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Updated: Apr 5, 2026

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
Published on: May 27, 2021
Evaluation of a cognitive psychophysiological model for management of tic disorders: an open trial
Kieron O'Connor1, Marc Lavoie2, Pierre Blanchet2
1Kieron O'Connor, PhD, Marc Lavoie, PhD, Pierre Blanchet, MD, Marie-Ève St-Pierre-Delorme, Research Centre, University Institute of Mental Health at Montreal, Canada kieron.oconnor@umontreal.ca.
Background:
Tic disorders, in particular chronic tic disorder and Tourette syndrome, affect about 1% of the population. The current treatment of choice is pharmacological or behavioural, addressing tics or the premonitory urges preceding tic onset.
Aims:
The current study reports an open trial evaluating the effectiveness of a cognitive psychophysiological treatment addressing Tourette-specific sensorimotor activation processes rather than the tic.
Method:
Forty-nine people with Tourette syndrome and 36 people with chronic tics completed 10 weeks of individual cognitive psychophysiological therapy. Outcome measures included two tic severity scales and psychosocial measures.
Results:
Post-treatment both groups had significantly improved on the tic scales with strong effect sizes across tic locations and complex and simple tics, maintained at 6-month follow-up with further change in perfectionism and self-esteem.
Conclusions:
The cognitive psychophysiological approach targeting underlying sensorimotor processes rather than tics in Tourette's and chronic tic disorder reduced symptoms with a large effect size.
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