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Updated: Apr 5, 2026

Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid
Published on: April 11, 2019
Umbilical Cord Blood-An Untapped Resource: Strategies to Decrease Early Red Blood Cell Transfusions and Improve
1Women and Newborn's Program, Intermountain Healthcare, 36 South State Street, Salt Lake City, UT 84111, USA; Neonatal Services, Dixie Regional Medical Center, 544 East 400 South, St George, UT 84770, USA.
Umbilical cord blood offers immediate benefits for newborns. Strategies like delayed cord clamping and cord milking increase infant blood volume and reduce the need for neonatal phlebotomy.
Area of Science:
- Neonatal Medicine
- Pediatrics
- Obstetrics
Background:
- Umbilical cord blood is a readily available resource for all neonates.
- Immediate post-delivery interventions can directly benefit the newborn infant.
- Current practices may involve neonatal phlebotomy for laboratory testing.
Purpose of the Study:
- To explore the benefits of utilizing umbilical cord blood for neonates.
- To evaluate methods for increasing neonatal blood volume post-delivery.
- To assess alternatives to direct neonatal phlebotomy.
Main Methods:
- Delayed umbilical cord clamping.
- Umbilical cord milking.
- Utilizing cord blood for neonatal laboratory testing.
Main Results:
- Delayed clamping and cord milking transfuse additional fetal blood to the neonate.
- Umbilical cord blood can be used for neonatal laboratory testing, avoiding direct phlebotomy.
- These strategies increase initial neonatal blood volume and minimize immediate blood loss.
Conclusions:
- Umbilical cord blood management offers significant advantages for newborns.
- Delayed cord clamping and cord milking are effective in increasing neonatal blood volume.
- Alternative uses of cord blood reduce the need for invasive procedures in neonates.
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