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Structure and Function of Platelets

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Related Experiment Video

Updated: Apr 5, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Neonatal Platelet Function.

Antonio Del Vecchio¹, Mario Motta², Costantino Romagnoli³

¹Neonatal Intensive Care Unit, Di Venere Hospital, Via Ospedale Di Venere n.1, Bari 70131, Italy.

Clinics in Perinatology

|August 8, 2015

Summary

This summary is machine-generated.

Neonatal platelet hyporeactivity, or reduced platelet function, is normal in the first few days of life. Persistent hyporeactivity after ten days may indicate a platelet disorder in newborns.

Keywords:

Megakaryocytes Neonatal hemostasis Platelet hyporeactivity Platelets Primary hemostasis Thrombocytopoiesis

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Published on: April 2, 2013

Area of Science:

Neonatal physiology
Hematology
Developmental biology

Background:

Platelet production and function undergo age-dependent changes in neonates, similar to the developing plasma coagulation system.
Neonates exhibit generalized platelet hyporeactivity in the initial days of life.

Purpose of the Study:

To characterize the developmental trajectory of platelet function in newborns.
To establish a timeline for the resolution of neonatal platelet hyporeactivity.

Main Methods:

Platelet function testing was performed on cord blood and peripheral blood samples from neonates.
Analysis focused on the period from birth through the first ten days of life.

Main Results:

A generalized platelet hyporeactivity was observed in cord blood and peripheral blood during the first days of life.
Normal adult levels of platelet reactivity were achieved between the fifth and ninth day of life.

Conclusions:

Neonatal platelet hyporeactivity is a transient physiological phenomenon.
Persistent hyporeactivity beyond ten days of life warrants further investigation for potential platelet disorders.