Related Experiment Video
Updated: Apr 5, 2026
17:38
Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
Published on: April 27, 2012
16.2K
Radiogenomics: what it is and why it is important
1Department of Radiology, Duke Cancer Institute, Duke Medical Physics Program, Duke University School of Medicine, Durham, North Carolina.
Journal of the American College of Radiology : JACR
|August 8, 2015
Summary
Radiogenomics, the study of imaging and genomics, offers practical insights for cancer research. It leverages incomplete data to improve decision-making and enhance patient outcomes, despite current limitations.
Area of Science:
- Oncology
- Radiology
- Genomics
Background:
- Emerging field connecting imaging phenotypes with genomic data.
- Radiogenomics (or imaging genomics) is a novel research direction.
- Addresses the practical significance of this relationship for cancer patient outcomes.
Purpose of the Study:
- To evaluate the practical significance of radiogenomics in improving cancer patient outcomes.
- To discuss the role of radiogenomics in overcoming data limitations in cancer research.
Main Methods:
- Review and analysis of the radiogenomic approach.
- Discussion of limitations and scenarios where radiogenomic analysis may not be optimal.
- Argument for the practical utility of radiogenomics.
Main Results:
- Radiogenomics has practical limitations but will play a significant role.
- Its significance is tied to current data challenges like incomplete patient characterization and poor dataset integration.
- Offers a method to utilize limited data for knowledge generation.
Conclusions:
- Radiogenomics provides a practical strategy to leverage incomplete datasets in cancer research.
- It facilitates improved decision-making, ultimately aiming for better patient outcomes.
- Despite limitations, radiogenomics is poised to be a valuable tool in oncology.
Related Concept Videos
02:02Genomics
41.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.8K
02:11Reporter Genes
13.8K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
13.8K
01:29Pharmacogenomics: Identification of New Drug Targets
86
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
86
01:28Isotopes and Radioisotopes
13.8K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
An isotope containing...
13.8K
01:29Pharmacogenetics and Pharmacogenomics: Overview
152
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
152
01:31Transducer Mechanism: Nuclear Receptors
6.0K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
6.0K