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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Apr 5, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

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[Key players in intestinal GVHD].

Daigo Hashimoto1, Takanori Teshima

  • 1Department of Hematology, Hokkaido University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|August 8, 2015
PubMed
Summary

Acute graft-versus-host disease (GVHD) impacts the gut after stem cell transplants. This review explores how intestinal barriers and microflora, regulated by key cells, influence GVHD.

Area of Science:

  • Immunology
  • Gastroenterology
  • Hematology

Context:

  • Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to acute graft-versus-host disease (GVHD).
  • The gastrointestinal tract is a primary target organ for GVHD.
  • Intestinal GVHD poses significant challenges due to treatment resistance and nutritional compromise.

Purpose:

  • To review recent findings on the role of the intestinal immune system in GVHD.
  • To highlight the significance of mucosal and microfloral barriers in intestinal GVHD.
  • To discuss the contribution of key cellular components to GVHD pathophysiology.

Summary:

  • The intestinal mucosa and microflora act as critical barriers in GVHD.
  • Intestinal stem cells, Paneth cells, innate lymphoid cells, and macrophages are key regulators.

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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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  • Understanding these components is crucial for managing intestinal GVHD.

    • Impact:

    • Provides insights into the mechanisms of intestinal GVHD.
    • Identifies potential therapeutic targets for improving GVHD outcomes.
    • Enhances understanding of the gut immune system's role in transplantation complications.