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Kidney Function and Cerebral Blood Flow: The Rotterdam Study.

Sanaz Sedaghat1, Meike W Vernooij2, Elizabeth Loehrer1

  • 1Departments of Epidemiology.

Journal of the American Society of Nephrology : JASN
|August 8, 2015
PubMed
Summary

Chronic kidney disease (CKD) is linked to brain issues. This study found lower estimated glomerular filtration rate (eGFR) is independently associated with reduced cerebral blood flow in adults.

Keywords:
GFRalbuminuriacerebral blood flowclinical epidemiology

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Area of Science:

  • Nephrology
  • Neurology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) is associated with various brain disorders.
  • Cerebral perfusion is crucial for brain integrity.
  • The relationship between kidney function and cerebral blood flow (CBF) requires further investigation.

Purpose of the Study:

  • To investigate the association between kidney function markers and CBF.
  • To determine if reduced kidney function is independently linked to lower CBF.

Main Methods:

  • Utilized data from the population-based Rotterdam Study (n=2645).
  • Assessed kidney function using estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR).
  • Measured CBF using phase-contrast magnetic resonance imaging of basilar and carotid arteries.

Main Results:

  • Higher ACR was associated with lower CBF in age- and sex-adjusted models.
  • This association between ACR and CBF was not significant after adjusting for cardiovascular risk factors.
  • Each 1 SD lower eGFR was independently associated with a 0.42 ml/min per 100 ml reduction in CBF, even after adjusting for cardiovascular risk factors.

Conclusions:

  • Lower estimated glomerular filtration rate (eGFR) is independently associated with reduced cerebral blood flow.
  • The findings suggest a potential link between impaired kidney function and cerebrovascular health.