Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[A method for choosing preparations that alter hemoglobin binding to oxygen].

M B Plotnikov, B I Laptev, T M Plotnikova

    Farmakologiia I Toksikologiia
    |November 1, 1989
    PubMed
    Summary

    This study introduces a straightforward method to assess how drugs impact hemoglobin oxygen affinity. By measuring oxygen saturation in blood samples, researchers can determine drug effects on oxygen transport.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adrenomedullin in Blood Plasma in Normotensive and Spontaneous Hypertensive Rats: Effect of Increased Blood Viscosity.

    Bulletin of experimental biology and medicine·2025
    Same author

    The Effect of Tryptanthrin and Its Oxime on the Blood-Brain Barrier Permeability in Rats with Cerebral Infarction.

    Bulletin of experimental biology and medicine·2025
    Same author

    Antioxidant Effects of Tryptanthrin Oxime.

    Bulletin of experimental biology and medicine·2024
    Same author

    Cardioprotective Action of the JNK Inhibitor Tryptanthrin Oxime in the Late Period after Myocardial Infarction.

    Bulletin of experimental biology and medicine·2024
    Same author

    Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats.

    Bulletin of experimental biology and medicine·2024
    Same author

    Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats.

    Bulletin of experimental biology and medicine·2024

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Hematology

    Background:

    • Hemoglobin oxygen affinity is crucial for effective oxygen delivery to tissues.
    • Understanding drug interactions with hemoglobin is vital for drug development and clinical use.

    Purpose of the Study:

    • To propose a simple and effective method for evaluating the influence of drugs on hemoglobin oxygen affinity.

    Main Methods:

    • The method involves measuring hemoglobin oxygen saturation (HbO2 %) in blood samples.
    • Samples are analyzed with and without the presence of specific drugs.
    • Gas mixture saturation (4% O2, 5% CO2, 91% N2) is used to standardize conditions.

    Main Results:

    • The proposed method allows for the quantitative estimation of drug-induced changes in HbO2 %.
    • This provides a direct measure of how drugs affect hemoglobin's ability to bind and release oxygen.

    Conclusions:

    • The developed technique offers a practical approach for investigating drug effects on hemoglobin oxygen affinity.
    • This method can aid in the preclinical assessment of pharmaceuticals impacting oxygen transport.

    Related Experiment Videos