Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heparin kinetics in vascular surgery.

N N Williams1, P J Broe, P Burke

  • 1Department of Surgery, Royal College of Surgeons, Beaumont Hospital, Dublin, Ireland.

European Journal of Vascular Surgery
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare Workers Beliefs about COVID-19; a Longitudinal, Mixed Methods Analysis.

Psychology, health & medicine·2022
Same author

Appendicitis and the COVID pandemic; new challenges in the management of a familiar foe.

The British journal of surgery·2020
Same author

Emotional outcomes in clinically isolated syndrome and early phase multiple sclerosis: a systematic review and meta-analysis.

Journal of psychosomatic research·2019
Same author

Cutting through the fat: a retrospective analysis of clinical outcomes, cost, and quality of life with the addition of panniculectomy to ventral hernia repair in overweight patients.

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery.

Vascular and endovascular surgery·2015
Same author

The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial.

Atherosclerosis·2015
Same journal

Intermittent claudication.

European journal of vascular surgery·1994
Same journal

Thoracoscopic sympathectomy.

European journal of vascular surgery·1994
Same journal

Thoracoscopic sympathectomy.

European journal of vascular surgery·1994
Same journal

Thoracoscopic sympathectomy.

European journal of vascular surgery·1994
Same journal

Aberrant right subclavian artery.

European journal of vascular surgery·1994
Same journal

An exceptional case of popliteal entrapment syndrome.

European journal of vascular surgery·1994
See all related articles

This study found that surgical trauma does not significantly alter heparin sensitivity in vascular surgery patients. Excessive heparin doses may be commonly used, as plasma heparin levels were not reliable indicators of anticoagulant effect.

Area of Science:

  • Vascular Surgery
  • Pharmacokinetics
  • Anesthesiology

Background:

  • Limited data exists on heparin efficacy and kinetics during vascular surgery.
  • Surgical trauma's impact on heparin's effects is not well understood.

Purpose of the Study:

  • To evaluate heparin kinetics during major vascular surgery.
  • To assess the influence of surgical trauma on heparin's anticoagulant effects.

Main Methods:

  • Nine patients undergoing major vascular surgery were studied.
  • Activated partial thromboplastin time (APTT) and plasma heparin levels were measured pre- and intra-operatively.
  • Heparin was administered intravenously at 100 u/kg body weight.

Main Results:

Related Experiment Videos

  • Mean APTT levels increased significantly, remaining over 2.5 times control at 2 hours post-administration.
  • Plasma heparin levels were similar across patients, but APTT results varied significantly.
  • Plasma heparin concentration was not a reliable indicator of anticoagulant effect.

    • Conclusions:

    • Surgical trauma does not appear to significantly alter patient sensitivity to heparin.
    • Current heparin dosing in vascular surgery may be excessive.
    • APTT is a more reliable measure of heparin's anticoagulant effect than plasma heparin levels.