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Accelerated partial breast irradiation with brachytherapy: patient selection and technique considerations
Daniel M Trifiletti1, Kara D Romano1, Shayna L Showalter2
1Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Breast Cancer (Dove Medical Press)
|August 8, 2015
Summary
Accelerated partial breast irradiation (APBI) using breast brachytherapy offers shorter treatment and less normal tissue exposure. This review compares existing guidelines for selecting patients for APBI, exploring unique patient and technical factors.
Area of Science:
- Oncology
- Radiotherapy
- Medical Physics
Background:
- Accelerated partial breast irradiation (APBI) via breast brachytherapy is a modern radiotherapy approach.
- It is favored internationally for reduced treatment duration and normal tissue irradiation.
- Favorable cancer-specific and cosmetic outcomes are maintained with APBI.
Purpose of the Study:
- To review, compare, and critique existing patient selection guidelines for APBI.
- To explore unique patient and technical selection factors for APBI with brachytherapy.
- To address conflicting recommendations among current guidelines.
Main Methods:
- Systematic review of existing patient selection guidelines for APBI.
- Comparative analysis of guideline recommendations.
- Categorization of guidelines and exploration of selection factors.
Main Results:
- Multiple consensus guidelines for APBI patient selection exist, with some conflicting recommendations.
- APBI is increasingly offered to select patients and included in national guidelines.
- Unique patient and technical factors influencing APBI selection were identified.
Conclusions:
- Patient selection for APBI remains complex due to varied guidelines.
- Further clarification and standardization of selection criteria are needed.
- APBI with brachytherapy is a viable option for select breast cancer patients, requiring careful consideration of individual factors.
