Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testing for course patterns in Crohn's disease using clustering analysis.

L Beaugerie1, Y Le Quintrec, J C Paris

  • 1Service de Gastroentérologie, Hôpital Rothschild, Paris.

Gastroenterologie Clinique Et Biologique
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remdesivir emergency approvals: a comparison of the U.S., Japanese, and EU systems.

Expert review of clinical pharmacology·2020
Same author

Medicine safety in pregnancy and ambitions for the EU medicine regulatory framework.

Clinical pharmacology and therapeutics·2016
Same author

[Anatomic study of the submental artery relationships for submental flap raising].

Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale·2016
Same author

Determinants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
Same author

Gait speed or gait variability, which one to use as a marker of risk to develop Alzheimer disease? A pilot study.

Aging clinical and experimental research·2015
Same author

[Patient treated with sub-mental intubation for maxillofacial trauma].

Annales francaises d'anesthesie et de reanimation·2014

Clustering analysis identified two Crohn's disease patient groups: one with persistent active disease and another achieving remission within two years. Early clinical data, except occlusive syndrome, did not predict these distinct Crohn's disease courses.

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Biostatistics

Background:

  • Crohn's disease is a chronic inflammatory bowel disease with variable clinical courses.
  • Predicting disease trajectory is crucial for effective patient management and treatment strategies.

Purpose of the Study:

  • To identify distinct patient subgroups based on disease course using clustering analysis.
  • To investigate if initial clinical data can predict these identified disease trajectories in Crohn's disease.

Main Methods:

  • Clustering analysis was applied to 177 Crohn's disease patients followed for at least 3 years.
  • Monthly clinical scores over the first 36 months served as active variables for grouping.
  • Patient groups were characterized by disease activity persistence or remission over the follow-up period.

Related Experiment Videos

Main Results:

  • Two distinct disease course groups (A and B) emerged, comprising 95 and 82 patients, respectively.
  • Group A exhibited persistent active disease at 3 years (unfavorable course).
  • Group B achieved clinical remission within an average of 2 years (favorable course), with a higher incidence of occlusive syndrome.

Conclusions:

  • The study suggests two primary Crohn's disease course patterns exist.
  • Disease course appears to manifest within the first two years and is not reliably predicted by initial clinical parameters, with occlusive syndrome being a potential indicator for a more favorable outcome.