Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1]
Yi Dong1,2, Nana Du1,2, Xueyuan Li2
1†Tsinghua-Peking Center for Life Sciences, Handian Dist., Beijing 100084, P. R. China.
Abstract:
A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.
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