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Updated: Apr 5, 2026
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Published on: June 2, 2014
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Migraine Management During Menstruation and Menopause
Continuum (Minneapolis, Minn.)
|August 8, 2015
Summary
Menstrual and menopausal migraines in women can be effectively managed with targeted medical and hormonal strategies. Understanding hormonal influences is key to reducing migraine disability.
Area of Science:
- Neurology
- Reproductive Endocrinology
Background:
- Migraine predominantly affects women of reproductive age.
- Hormonal fluctuations, particularly estrogen withdrawal, are linked to menstrual migraine.
- Menopause also presents unique migraine challenges.
Purpose of the Study:
- To review the impact of hormonal events on migraine.
- To summarize evidence-based management options for hormone-related migraines.
Main Methods:
- Literature review of studies on hormonal influences and migraine.
- Analysis of current treatment strategies for menstrual and menopausal migraine.
Main Results:
- Estrogen withdrawal is a known factor in menstrual migraine, but other mechanisms may also be involved.
- Prostaglandin inhibitors show efficacy for menstrual migraine, suggesting shared pathways with dysmenorrhea.
- The interaction between serotonin and estrogen warrants further investigation.
Conclusions:
- Menstrual and perimenopausal migraines are manageable with diverse strategies.
- Treatment selection depends on acute treatment efficacy, menstrual regularity, contraceptive use, and menopausal symptoms.
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