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The association between plasma thiol levels and left ventricular diastolic dysfunction in patient with hypertension

Musluhittin Emre Erkus1, Ibrahim Halil Altiparmak1, Ali Riza Akyuz2

  • 1a Department of Cardiology , Harran University Faculty of Medicine , Sanliurfa , Turkey.

Scandinavian Journal of Clinical and Laboratory Investigation
|August 8, 2015
PubMed

Insights

Plasma thiol levels are linked to left ventricular diastolic dysfunction (LVDD) in hypertension. Lower thiol levels predict LVDD, suggesting a protective role for thiols in maintaining heart function.

Area of Science:

  • Cardiology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Oxidant-antioxidant balance is crucial for left ventricular diastolic dysfunction (LVDD) in hypertension (HT).
  • Plasma thiol, a key component of the body's antioxidant system, has not been extensively studied in relation to LVDD in hypertensive patients.

Purpose of the Study:

  • To investigate the relationship between plasma thiol levels and LVDD in patients with essential hypertension.
  • To determine if plasma thiol levels can predict the presence and severity of LVDD.

Main Methods:

  • 138 newly diagnosed essential hypertensive patients and 20 controls underwent echocardiography.
  • Plasma thiol, lipid, and glucose levels were measured.
  • Hypertensive patients were categorized by LVDD grade (none, grade 1, grade 2).
  • Multivariate analyses and ROC-curve analysis were performed.

Main Results:

  • Plasma thiol levels differed significantly across groups, with the lowest levels in patients with higher LVDD grades.
  • LVDD presence correlated with age, blood pressure, thiol levels, coronary artery disease, and hyperlipidemia.
  • Age and plasma thiol levels were independent predictors of LVDD.
  • Thiol levels >163 μmol/L predicted LVDD with 75% sensitivity and 70% specificity (AUC = 0.783).

Conclusions:

  • Plasma thiol is an independent predictor for the presence of LVDD in hypertensive patients.
  • Thiol appears to play a role in the pathogenesis of diastolic dysfunction.
  • Higher plasma thiol levels may offer protection against the development of diastolic dysfunction.

Keywords:
Antioxidantsdiastolic heart failurehypertensionredoxthiol

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