A [2+2+2]-Cyclotrimerization Approach to Selectively Substituted Fluorenes and Fluorenols, and Their Conversion to
Reinhard P Kaiser1, Filip Hessler1, Jiří Mosinger2
1Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Albertov 6, 128 43 Praha 2 (Czech Republic).
Abstract:
Synthesis of selectively substituted fluorenes and fluorenols was achieved by using catalytic [2+2+2]cyclotrimerization. Various starting diynes were reacted with different alkynes in the presence of a catalytic amount of Wilkinson's catalyst (RhCl(PPh3)3) providing the compounds possessing the fluorene scaffold in good isolated yields. A set of four regioselectively substituted fluorenols was converted to the corresponding 9,9'-spirobifluorenes and their spectral characteristics were measured.
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